Palladium(II) N^O Chelating Complexes Catalyzed One-Pot Approach for Synthesis of Quinazolin-4(3<i>H</i>)-ones via Acceptorless Dehydrogenative Coupling of Benzyl Alcohols and 2-Aminobenzamide

A convenient protocol for the one-pot synthesis of quinazolin-4(3H)-ones using palladium(II) complexes via dehydrogenative coupling readily available benzyl alcohols and 2-aminobenzamide has been described. New structurally related Pd(II) N^O chelating general configuration [Pd(L)Cl(PPh3)] (where L = dimethylamino benzoylhydrazone ligands) have designed synthesized. The formation recognized by analytical spectral methods (FT-IR, NMR, HR-MS). presence a square-planar geometry around ion was confirmed single crystal X-ray diffraction study. wide range substituted quinazolinones successfully achieved from diverse in good to excellent yields 1.0 mol % catalyst loading under aerobic conditions. Furthermore, control experiments reveal that reaction involves initially an aldehyde intermediate subsequent cyclic aminal intermediate.